标签归档 西安品茶上课

How is the domestic beauty explosion made?

Customers are trying on makeup at the Perfect Diary Guangzhou Zhengjia Store. Perfect diary for the picture

A joint lip balm jointly launched by shanghai jahwa’s Meijiajing and White Rabbit. Photo courtesy of Tmall

The perfect diary and the 16-color eye shadow jointly launched by China National Geographic magazine. Perfect diary for the picture

On the cosmetics track, China brand is facing the situation of "falling behind at the start". China customers really began to accept the concept of cosmetics consumption after the reform and opening up, but at this time, foreign brands have accumulated huge advantages in capital, technology and publicity.

However, local cosmetics companies have not been "routed" as many people feared, but have gradually gained a foothold. What’s the secret? In recent years, a number of emerging domestic beauty brands have emerged, which makes consumers exclaim "the light of domestic products". What are the reasons behind it?

The reporter visited two China cosmetics companies: shanghai jahwa and Yixian E-commerce. The former is a century-old shop established in 1898, and it owns famous brands such as herborist, Liushen, Yuze and Meijiajing. The latter is a cutting-edge market that was born in 2016, and its "perfect diary" has become one of the hottest domestic makeup brands in recent years. Through their stories, we may be able to find the answer to the rise of domestic cosmetics.

Shanghai jahwa: a century-old shop with a new look.

In 1915, the cosmetics "Shuangmei" brand "Pink Cream" from China won the gold medal in the evaluation of Panama World Expo in San Francisco, USA.

This "Shuangmei" brand, which was widely welcomed by celebrities at that time, was produced by China Guangshenghang, one of the oldest national enterprises in the daily chemical industry, which was established in 1898. After the founding of New China, Guangshenghang changed its name to "Shanghai Household Chemicals Factory" after several reforms, mergers and reorganizations, which is today’s shanghai jahwa. Its brands such as "Meijiajing" Pearl Tremella Cream and "Ya Shuang" Cream, which were launched in the 1960s, have long been the collective memory of generations of Chinese people.

However, even shanghai jahwa, a local industry leader with profound knowledge, has a big gap with international cosmetics giants in terms of technology accumulation and market expansion. However, shanghai jahwa skillfully used the strategy of "Tian Ji Horse Racing" and broke out his own road of differentiated development.

The second trick is to "avoid its sharpness and open up a new track for Chinese medicine." No matter at home or abroad, consumers have a common pursuit for the "natural" attribute of cosmetics. Traditional Chinese medicine has a unique advantage as a cosmetic raw material because of its natural selection of materials and outstanding efficacy. If there is a clear gap between China enterprises and foreign brands in chemical technology in consumers’ impression, the gap is not obvious in the new track of Chinese medicine cosmetics, and even China enterprises are more knowledgeable.

Shanghai jahwa keenly grasped this point, and used the compound concept of "monarch, minister and assistant" in traditional Chinese medicine (that is, blindly taking Chinese medicine as the main ingredient, supplemented by several flavors) to prepare raw materials, thus creating a unique brand of Chinese herbal medicine cosmetics "herborist". "herborist" was a great success once it was launched. In 2008, it entered the Sephora cosmetics store on the Champs Elysé es, becoming the first cosmetics brand in China to go abroad.

"Domestic brands have a better understanding of China consumers and are better at telling brand stories with Chinese expressions." When summing up the competitive advantages of China brands and foreign brands, the relevant person in charge in shanghai jahwa told reporters. At the same time, the new product development of foreign brands often needs to be approved by the headquarters first, and shanghai jahwa believes that "local enterprises have a faster response speed in decision-making, consumer communication and channel adjustment and upgrading."

For the cosmetics market in China, it is easy to make a single "explosion" with differentiation strategy, but it is difficult for enterprises to grow at a high speed for a long time. Since 2003, local brands such as "Little Nurse", "Dabao" and "Ding Jiayi" have been acquired by foreign investors, and then they have been silent. Some insiders believe that relying too much on a single product is one of the reasons why these local enterprises are unsustainable.

In this regard, shanghai jahwa decisively adopted a multi-brand strategy to build its own "moat". On the one hand, the continuous research and development of "herborist" series of new products impacts the mid-to high-end market, on the other hand, it creates brands in different market segments. For example, in view of young people’s oily and sensitive dry skin, shanghai jahwa and Shanghai Ruijin Hospital developed "Yuze" series, which is the first medical skin care brand jointly developed with hospitals in China. At the same time, it has also developed "Goufu" which focuses on men’s skin care, and "Kaichu" which aims at the maternal and infant care market.

Behind the establishment of brand matrix in shanghai jahwa, there is high-intensity research and development as the support. The 2019 financial report shows that shanghai jahwa’s total R&D investment reached 183 million yuan, which is in a leading position in the domestic industry, and its R&D ratio of 2.41% is close to the level of international brands such as L ‘Oré al and Shiseido.

On May 6th this year, shanghai jahwa welcomed Pan Qiusheng, the new chairman and CEO. In a letter to employees, Pan Qiusheng bluntly said: The past few years have witnessed rapid development and evolution of the daily chemical and beauty cosmetics market in China, and the cognition and pursuit of beauty of a new generation of young consumers have changed greatly.

Shanghai jahwa, a century-old shop, is actively adjusting its attitude, trying to find ways that young consumers like and establish emotional links with them. In terms of understanding young people, this emerging domestic beauty brand may provide some useful experience.

Perfect diary: attracting more young people

Compared with the century-old history of shanghai jahwa, Perfect Diary is definitely a "young man" in the cosmetics market in China. But the report card of this "young man" should not be underestimated.

According to Chen Yuwen, co-founder of Perfect Diary’s parent company, Yixian E-commerce, at present, the fans of Perfect Diary have exceeded 25 million, and the monthly exposure has exceeded 1 billion. In this year’s "Queen’s Day 38" promotion, the perfect diary’s cat eye shadow tray and puppy eye shadow tray were sold out within 4 minutes, setting a record of selling 2,000 pieces per second …

In the capital market, the performance of Perfect Diary is also very bright: four rounds of financing have been completed in four years, with a valuation of 2 billion US dollars. Among the investors, there are many well-known institutions such as Zhenge Fund, Gaochun Capital and Gaochun Capital.

Why does a startup company established in 2016 dare to enter the cosmetics market surrounded by "strong enemies"?

In Chen Yuwen’s view, because the cosmetics market in China has entered an era of drastic changes: the market is changing, the channels are changing, and consumers are changing. These changes together constitute the "right time and place" of emerging domestic beauty products.

"Compared with countries with similar GDP levels, China’s beauty penetration rate is low. We judge that there is still a lot of market space for beauty products in China." Chen Yuwen told reporters that in 2017, the penetration rate of Japanese and Korean cosmetics has exceeded 80%, while that of China is only 30%.

"On the other hand, it is the emergence of the Internet." Chen Yuwen said that the rapid development of cmnet, e-commerce and social media, on the one hand, has built an online channel for Perfect Diary to communicate directly with young consumers, on the other hand, it has also provided accurate data, which can provide very timely and powerful guidance for its development of new product categories and needs. "So we chose the beauty track and chose the Internet as the core." Chen Yuwen said.

But the more important change is the change of people. Behind the rise of new brands is often the rise of new consumer groups.

The users of the perfect diary are accurately positioned as young women aged 18-28, of which "after 00" accounts for 50% and "after 95" accounts for 70%. "This is a generation that grew up with the Internet. According to our observation, they have a broader vision, are open and confident, like creativity, and generally have a higher acceptance of domestic brands than before." Chen Yuwen said that the new generation of consumers are just beginning to get in touch with makeup products, but the prices of foreign brands are on the high side for them, which brings good opportunities to new domestic brands.

Therefore, it is the breakthrough point for the perfect diary to enter the beauty market to let the post-1995 generation in China buy products with similar quality to international brands, but with much lower prices and more innovative ideas. This "parity substitution" strategy for international brands has also become an important source of its product strength.

The way to ensure quality is to cooperate with high-quality foundries. Perfect Diary found Cosme Meishi, the world’s largest cosmetics foundry, for its own production. The latter is also a cooperative foundry of international brands such as Dior, L ‘Oreal and Lancome, and the price of similar products is only about half that of international brands.

The way to renew creativity is to let consumers become designers. Perfect Diary not only analyzes product reputation and fan preferences through data, but also directly communicates product solutions with consumers, allowing consumers to deeply participate in all aspects of product design.

"In fact, the quality of domestic cosmetics is not worse than that of foreign brands. Foreign brands can sell premiums in the China market, and most of them are brand additions." Chen Yuwen said, "And we pay attention to originality. When the perfect diary is ahead of many international brands in visual style and product creativity, consumers will naturally choose us."

However, Chen Yuwen also remained calm. He bluntly said that if domestic brands rely too much on foundries, there is no way out, so Perfect Diary is also increasing investment in research and development. This year, Perfect Diary and Cosme Meishi invested 700 million yuan to start building the largest cosmetics production base in Asia, and at the same time, they are cooperating with Sun Yat-sen University to establish a research and development laboratory. "In the next three years, we expect to invest no less than 100 million yuan in research and development."

Comparing the development process of shanghai jahwa and Perfect Diary, the common point is that they have completed the first two steps of "understanding consumer demand, developing differentiated products and establishing brand moat", and are striving for the third step. Whether "Big Brother" shanghai jahwa is transforming into a younger generation, increasing its investment in online communities such as Little Red Book, bilibili and Tik Tok, or opening hundreds of offline experience stores under the "Young People’s Perfect Diary" transformation, although it seems to be in the opposite direction, its essence is the improvement of its own channel shortcomings and the reinforcement of its own brand moat in a rapidly changing environment.

The market potential of China is large enough, and there are more and more new changes in domestic cosmetics. In the future, can "China Cleaning" or "L ‘Oré al China" be born in this hot land? We will wait and see.

20 games with the highest IGN score in 2023: two perfect works!

The future game lineup of each family has gradually stabilized this year, and many masterpieces will be launched one after another in 2023. All three host manufacturers are planning their own blockbuster works in 2023. At present, the first quarter has passed, and IGN has published a summary of 20 high-scoring games so far this year, two of which are full marks. Let’s take a look.

Full list:

8 step:

Heart of the atom

Multi-player part of company of heroes 3

I wish you a good death

Meet the Creator

Resident Evil: Village VR

Son of the forest

Wild heart

Wolong: The Fall of Heaven

《WWE 2K23》

9 step:

Bayonetta: Origin

Dead Space: Remastered Edition

Flame coat of arms Engage

《GT7 VR》

《Hi-Fi Rush》

The legacy of Hogwarts

Major League Baseball 23

Pizza tower

Final fantasy rhythm theater

10 step:

Galactic warrior Prime replica edition

Resident Evil 4: Remastered Edition

1-1! The suspense of the Premier League battle continues, and Liverpool’s seven-game winning streak has ended. It takes a miracle to enter the Champions League!

Tonight, the first in the Premier LeaguethreesevenTwo major events were staged at the same time, and the fate of the two competing for the four giants was ice and fire, and Manchester United was away.one-0Beat bournemouth,Expand the leading edge,Liverpool home1-1TiedAston villa,Fall behind Manchester UnitedthreeDivide!As a result, the Premier League is in suspense for four.Keep it still, Newcastle and Manchester UnitedJust take it againonePoints can ensure that beforefour,butLiverpoolNeed to wait for a miracle to happen..

Manchester United led Liverpool before the game.1 point, and one less game, firmly grasp the initiative to fight for four. With two rounds left in the league, Liverpool must guarantee a total victory and expect Manchester United to lose points before they can have a chance to come from behind. This round of Liverpool ushered in Aston Villa, which played well in the second half. Coach klopp was suspended and could only watch the game in the stands, while Manchester United’s opponent was Bournemouth, who had already relegated in advance.

This round of Manchester United and Liverpool started at the same time, and the fate of the two teams appeared in the first half. With casemiro’s goal, Manchester United took the lead early and played the following games with ease. Liverpool, on the other hand, was in a bad state. After dodging the penalty, Ramsey scored the goal for the visiting team, klopp was in a hurry in the stands, and the performance of the Red Army did not improve.

In the second half, there was no change in the scores of the two games.,Manchester United’s game is over first, they are away.1-0Win.Subsequently, firmino, who came off the bench, equalized the score and finally played at home.1-1Draw with Aston Villa. In this way, Newcastle and Manchester United are leftTwoField situation, ahead of Liverpool.onePoints (onlyoneField), just take it again.onePoints can ensure that beforefour.Liverpool must win in the last round and then expect Newcastle or Manchester United to suffer.TwoLosing in a row, with the advantage of goal difference, it is quite difficult.For the management of klopp and Liverpool, this season’s performance is a disaster, and the lineup must be changed this summer!


Shuxiang Zhiyuan The First Sun Yat-sen Soong Ching Ling Reading Marathon was launched in Shanghai.

The first "Progress Cup" Sun Yat-sen Soong Ching Ling Reading Marathon was launched in Xujiahui Academy. Photo courtesy of the contest organizer

Xu Jing, April 17 (Xinhua) The year 2023 marks the 130th anniversary of the birth of Soong Ching Ling, one of the founders of People’s Republic of China (PRC) and honorary president of the country. The launching ceremony of the first "Progress Cup" Sun Yat-sen Soong Ching Ling Reading Marathon (hereinafter referred to as "Yuema") and the launching ceremony of the question bank were held in Shanghai on the 17th.

The contest was hosted by the Shanghai Sun Yat-sen Soong Ching Ling Cultural Relics Management Committee and the Shanghai Committee of the Communist Youth League, and co-hosted by the Shanghai Soong Ching Ling Former Residence Memorial Hall and Xuhui District Culture and Tourism Bureau.

In this competition, a series of related books, such as Soong Ching Ling, Sun Yat-sen and so on, were read by combining offline and offline, so as to attract a wide audience, including teenagers, to read the grand and magnificent life stories of two great men in the century and approach their three-dimensional and vivid spiritual world.

The contest calls on the whole people to read the works of celebrities intensively and enjoy reading. Photo courtesy of the contest organizer

Soong Ching Ling is the daughter of Shanghai. Her "lovely home" is located in Xuhui, Shanghai, and most of the women’s and children’s cultural and educational undertakings she initiated in her life germinated, took root, flourished and expanded in Xuhui. The launching ceremony of this competition was held in Xujiahui Academy, one of Shanghai’s cultural landmarks. By setting up "Soong Ching Ling’s special bookcase" in this all-media era compound library and entering the hospital to scan the code, the reading was switched online and offline, showing the power of reading to the society and calling on the whole people to read.

On the same day, 150 contestants were divided into student group and adult group. They read the book Soong Ching Ling together in three divisions of Xujiahui Academy, and completed the online question bank and made a comparison within the specified time. After the launching ceremony, various organizations and individuals will continue this "Yue Ma" lasting for 100 days, calling on the whole people to intensively read famous works, enjoy reading, pool their wisdom and enrich their spiritual world.

Ni Yifei, director of the Cultural Management Committee of Sun Yat-sen Soong Ching Ling in Shanghai, said that in recent years, the Cultural Management Committee of Sun Yat-sen Soong Ching Ling in Shanghai has continued to promote the construction of a "great mission" platform with the theme of carrying forward the great spirit of Sun Yat-sen Soong Ching Ling, with the series of activities of "five tours" (tour exhibition, lecture, broadcast, competition and tour) as the starting point to provide quality public cultural services to the public. The first "Progress Cup" Sun Yat-sen Soong Ching Ling Reading Marathon is a touring brand planned and launched by the Cultural Management Committee of Sun Yat-sen Soong Ching Ling in Shanghai this year.

Wu Bin, deputy secretary of the Shanghai Communist Youth League Committee, said that the Shanghai Communist Youth League Committee will widely mobilize the youth of the city to actively participate. I believe that through this competition, the contestants will learn something and learn something. With the joint efforts of many parties, this competition will definitely become a high-quality platform for "innovating the use of red resources and boosting the growth of young people". (End)

ChatGPT invested $180 million in anti-aging company, trying to increase the average life expectancy of human beings by 10 years.

In mid-2022, a startup company named Retro Biosciences came into public view, and it announced that it had obtained $180 million for a bold task: increasing the average life expectancy of human beings by 10 years. Just a short year ago, the company was headquartered in a warehouse near San Francisco. There were many containers on the concrete floor, where scientists worked and did experiments.

Retro said that as part of the "radical task", it would "stimulate the speed" and "tighten the feedback loop" in order to stop aging or even reverse it. But it is vague about the source of its funds. According to reports, it was still a "mysterious" startup, and its investors were anonymous.

Now MIT Science and Technology Review can reveal that all the investment was provided by Sam Altman, a 37-year-old senior entrepreneur and CEO of OpenAI.

Altman spent almost all his time on OpenAI, an artificial intelligence company, whose chat bots and electronic art programs have always been unique in the field of science and technology because of their comparable human capabilities.

But altman’s money is another matter. He said that he had emptied his bank account to fund two other very different but equally ambitious goals: pursuing unlimited energy and prolonging life.

He said in 2021 that one of the projects is Helion Energy, a nuclear fusion power generation startup, and he has invested more than 375 million US dollars in the company. The other is Retro, who invested a total of $180 million in the same year.

"This is a lot of money. I basically invested all my current assets in these two companies, "altman said.

Altman’s investment in Retro has never been disclosed before. This is one of the largest personal investments ever made by a startup company seeking to increase human life span.

Altman has always been a well-known figure in Silicon Valley. He used to run Y Combinator, a business incubator in San Francisco, but with the release of ChatGPT by OpenAI and its popularity all over the world, his name has been known all over the world.

It is reported that the breakthrough based on artificial intelligence technology has turned this seven-year-old company into a "member of the technology giant club". Microsoft promised to invest $10 billion in it, and altman, who has 1.5 million Twitter followers, is consolidating his status as a technology tycoon, and his invention will definitely change the society profoundly.

Altman is not on Forbes’ list of billionaires, but he is still very rich. His extensive investments include early shares in companies such as Stripe and Airbnb.

He said: "In the biggest bull market in history, I have always been an investor in technology stocks at an early stage."

Hard core technology

Now, in his words, he has invested his capital in a level that is "orders of magnitude far beyond the Y Combinator era". He has been betting these funds on several technical fields that he thinks will have the greatest positive impact on mankind: artificial intelligence, energy and anti-aging biotechnology.

Helion, headquartered in Everett, Washington, is eager to conquer atoms to create an "infinite clean energy". Joe Betts-LaCroix, CEO and co-founder of Retro, said that the company’s goal is to "prolong human life by discovering how to rejuvenate our bodies".

All these companies, including OpenAI, are what altman called "hard-core" start-ups-companies that need a lot of investment to make scientific progress and master difficult technologies. This is a shift for altman, from supporting fast-growing applications and companies in the era of Web 2.0 prosperity to supporting scientists engaged in long-term research.

Hard science companies need higher capital costs, but altman believes that their bigger goals are more likely to attract talented engineers. He recently quoted Daniel Burnham, a Victorian architect, on Twitter: "Don’t make small plans, they don’t have the magic to stimulate the blood flow."

Although nuclear fusion and life extension may be the most incredible projects (some researchers even think it’s daydreaming), few people believed that artificial intelligence would pass the medical school exam in 2023, just like ChatGPT, a chat robot of OpenAI, did this year.

Altman said that in fact, hard-core startups may have a better chance of success than simple companies. This is because there may be a thousand start-ups developing photo sharing applications, but only a few companies can build experimental nuclear fusion reactors.

enlarge the scale

Altman said that the areas he has been betting on are those where he can see some potential trends, so that technologies that seem impossible today are expected to spread quickly. This is what happened to OpenAI, which was established in 2015.

The company focuses on a machine learning technology called transformer and has steadily expanded its scale. In the process of creating its products, it only spent more than $1 billion on purchasing computing power.

The resulting model (program) can create pictures and complex text paragraphs in a few seconds, even close to human works. "We have an algorithm that we can learn, and as it performs more operations, it seems that it can be further extended," altman said.

As for the realization of controlled nuclear fusion, the trend that altman sees is bigger and stronger magnets. In order to fix the 100 million-degree thermal plasma vortex in the reactor core, we need very powerful magnets. Altman said that he initially invested about $10 million in Helion, but later increased the stakes because he was "very confident".

Although the problem of nuclear fusion has not been solved (reactors still use more energy than they produce), he has been urging Helion to list how to build several reactors every day-if nuclear fusion wants to replace coal and natural gas as the main power source, increasing production capacity is a necessary part.

"That’s what I’ve learned from my career. Scale it up and see what happens, "altman said.

Young blood

About eight years ago, altman became interested in the so-called "young blood" research. In these studies, scientists stitched young mice and old mice together so that they shared a blood system. Surprisingly, these old mice seem to have partially recovered their vitality.

This is a terrible experiment, but to some extent, it is very simple. Altman, then the head of Y Combinator incubator, asked his staff to investigate what progress anti-aging scientists were making.

He said: "It feels like this is a result I didn’t expect, and that is another result I didn’t expect. This means that something is happening quietly … Maybe there is a secret hidden here, and it is easier to find than we thought. "

In 2018, Y Combinator opened a special course for biotech companies, inviting companies with "radical anti-aging plans" to apply, but soon after, altman left Y Combinator to concentrate on his increasingly busy work in OpenAI.

By 2020, some researchers in California showed that they could achieve the effect similar to obtaining "young blood" by replacing the plasma of old mice with saline and albumin. This shows that the real problem lies in the "aging blood". Just by diluting it (and the toxins in it), we may be one step closer to drugs that resist or even cure aging.

Bates Lacroiva recalled, "Sam called me and said,’ My God, have you seen this plasma intervention paper?’ That’s not what I said, but the general idea is similar. Bates Lacroiva was a part-time biotechnology partner of Y Combinator and now leads a gathering of longevity lovers.

Bates Lacroix agrees that it’s cool and some companies should pursue it. "How about I fund you to do it?" Altman said.

But Bates Lacroix was already studying a different idea. He just finished an early joint venture project, a company called Vium. The company tried to "digitize" the rat population and added cameras and artificial intelligence to monitor the experiment. Vium has raised more than 50 million dollars, but it has not been successful. That year, it was merged into another biotechnology company, which bought its assets for $2.6 million.

Bates Lacroiva’s new plan is to set up a company to pursue cell reprogramming-another hot area involving the technology of making cells younger through genetic engineering. He has collaborated with Chinese scholar Ding Sheng Ding who has developed a new method of reprogramming cells. Bates-Lacroiva also believes that the process that cells use to process toxins (called autophagy) may be a direction worth exploring.

Altman’s answer is: "Why don’t you do all these things?"

"I will. I will set up a multi-project company around the biology of aging, which is a big project, "Bates Lacroiva recalled." Then he said,’ Great, let’s do it.’ "

The new company needs a lot of money-enough to keep it going for at least seven or eight years while conducting research, encountering setbacks and overcoming them. And it needs to finish the work quickly. The expenses of many biotech startups are decided by the board of directors, but in Retro, Bates-Lacroiva has all the decision-making power. "There is no bureaucracy here," he said. "I am a bureaucracy."

For example, Bates Lacroix did not wait for scarce laboratory space, but filled a warehouse with 40 prefabricated containers and used them as laboratories. This means that he can quickly carry out the first experiment, including repeating some plasma work on mice. Bates Lacroiva presented some preliminary results at a conference in 2022, saying that mice undergoing plasma exchange seemed to become stronger.

Mysterious start-up company

Retro employees submit experimental memos every week to record which work is progressing smoothly and which work is frustrated. Bates Lacroix said that he usually calls altman on weekends to tell him the highlights, and altman sometimes makes suggestions.

However, up to now, things related to this company in altman have been kept secret. This is a decision made by Bates Lacroiva, who wants Retro to open its own path. Altman agreed, because he tried to be "very careful not to hide the brilliance of the CEOs I worked with."

When Bates Lacroiva officially disclosed the company information in mid-2022, in a series of tweets, he still didn’t disclose altman’s name, but said that he was "lucky to get the initial capital of 180 million dollars", which was enough to "safely" support the company to run until 2030, when it planned to realize "the first proof of concept to extend life".

People familiar with the company’s thinking say it’s also because altman’s name may be a distraction. Of course, he is famous, but this reason may be wrong. Although altman’s position in the entrepreneurial world is unparalleled, his reputation is almost nonexistent in the biological laboratory and pharmaceutical industry, and a person’s scientific record is the most important in this circle.

"I’ve never heard of the name Sam altman," said Irina Conboy, a researcher at the University of California, Berkeley, although her work on plasma has amazed Sam. But she is really more familiar with Bates Lacroiva and his research on longevity.

"100 million is just a number, not a breakthrough," Comboy said.

Public discontent

Every technology also has risks. As far as artificial intelligence is concerned, it is chat bots that may spread lies and false information. As for reversing the age, if it is really effective, one of the risks often mentioned is public dissatisfaction, especially if it will be offered to the rich like altman first.

The basis of this idea is that if altman’s financial support is magnified conspicuously, Retro may become a victim and be classified as a vanity project misled by billionaires in pursuit of immortality.

We have reason to be so worried. In 2016, Peter Thiel, one of altman’s mentors, was ridiculed by the media as a "vampire looking for young victims" after he expressed interest in receiving anti-aging blood transfusion treatment. A year later, HBO’s spoof program "Silicon Valley" released an episode called "Blood Donation Boy". In the film, the CEO of a fictional technology company is in a meeting, and his vein is connected with that of a handsome young man called "blood transfusion assistant".

"We really don’t want to see those old billionaires pay for plasma donors," Bates Lacroiva said in the summer of 2022. Instead, he said, the company hopes to find more "credible" interventions, such as drugs that mimic the effect of blood replacement, for millions of people to use.

"We don’t want to treat billionaires with prejudice. I’m just saying that we don’t want to see treatments that are super expensive, awkward and difficult to implement. "

Altman said that his personal anti-aging methods include "trying to eat healthily, exercise and get enough sleep" and taking metformin. Metformin is a diabetes drug, but it is very popular in Silicon Valley because it may make people without diabetes healthier. "I hope I can use Retro therapy one day!" Altman said.

OpenAI in the field of anti-aging

Anti-aging research seems to be a promising investment field. One reason is that it has not received much funds in the past, at least relative to the scale of the research project. According to the data of the Center for Medicare and Medicaid Services in the United States-about $4.3 trillion, accounting for nearly one-fifth of the GDP of the United States-it is used for medical care, most of which is used to treat the elderly. Longevity researchers generally believe that if a drug can delay aging, it may help delay a series of serious diseases, including cancer and heart disease.

Bates Lacroiva said that in order to have the widest impact, he is looking for interventions that can scale up and affect "millions or billions" of people.

However, when Retro lifted the veil, the research on the problem of old age was becoming very popular. The Saudi government said that it will provide 1 billion dollars for related research every year, and an organization called Altos Laboratory has been established, claiming that it has 3 billion dollars. Famous investors are also involved, such as Yuri Milner, and even Jeff Bezos is rumored.

Compared with these investments, altman’s bet looks relatively small, even making Retro look insignificant. One of its projects is to test the rejuvenation technology on T cells, which are part of the immune system and play an important role in fighting infection and avoiding cancer.

These cells are particularly useful because they can be removed, rejuvenated in the laboratory and sent back to the patient. But other startups have similar goals, including Altos and NewLimit, a biotechnology company founded by cryptocurrency billionaire Brian Armstrong in 2022.

The competition for researchers is particularly fierce. Altos persuaded 24 university professors to leave their jobs and offered millions of dollars in salary and other benefits, which absorbed almost half of the top scientists in the field of reprogramming.

But Bates Lacroix also managed to attract some top talents. In 2022, he flew to Switzerland to visit Alejandro Ocampo, a researcher at Lausanne University. In 2016, Ocampo was the first scholar to study the rejuvenation of mice, and his research helped trigger the current craze for longevity investment.

"I’m glad to see Joe coming to see me in person," Ocampo said. He was so grateful for the attention he received that he later agreed to become a paid consultant for the company.

He also said that Bates Lacroiva is willing to accept his view that the age reversal of human beings will not happen in the short term. Some of Ocampo’s recent experiments explored why the reprogramming method he studied would kill some mice instead of making them live longer.

Ocampo said: "Some optimists think that we will achieve eternal life in 10 years, while some pessimists say that we will never prolong human life. As a realist, my personal opinion is that many people are choosing simple and fast experiments, but if we do the same, I don’t think we will go very far. Because this will not be an easy road. "

Ocampo said that Bates Lacroix convinced him that Retro was willing to explore these basic problems with its own funds. "They want to promote the development of science, not just pursue short-term goals," he said. "Other companies want to find an application scenario immediately, but they are willing to spend time exploring basic science."

Bates Lacroiva did not discuss Retro’s funding sources with Ocampo. Ocampo said that he didn’t know that altman was funding the startup until he was interviewed by MIT Science and Technology Review.

In an interview, altman didn’t worry about the competition from other companies. He believes that most biotechnology companies are accustomed to slow action and are usually "not good at management". He believes that the research on longevity needs an "OpenAI-style effort".

Altman said: "Retro’s main task is to become a truly excellent biological start-up company, because this is a rare thing. It combines great science with the resources of big companies in the spirit of a startup company. This is our current project. "

Original text:

The brand-new Chongqing team appeared in China football! The warm-up match defeated the newly promoted Super League, which made the fans sit up and take notice.

A few days ago, Chongqing football ushered in a brand-new professional league team, which is Chongqing Tonglianglong, which gathered many old Lifan generals. After the dissolution of the Chongqing team, Chongqing Tonglianglong began to play in the China Champions League and began to carry the banner of reviving Chongqing football. Chongqing Tonglianglong performed well in the Champions League last season and got the qualification of Chong B. After Chongqing Tongliang Dragon rushed to China B, it filled the gap that there was no professional team in Chongqing football.

Chongqing lifan used to be a strong football team in China, and it also performed well in the Super League, and once beat Evergrande. Chongqing team has also trained international players like Zhang Chiming and Feng Jin. Unfortunately, before the Super League started last season, the team once again encountered the crisis of unpaid wages. Finally, after comprehensive consideration, Chongqing team decided to quit professional football. Chongqing team quit professional football, which made Chongqing football lose its professional team.

At the critical moment, Chongqing Tonglianglong stood up, started to play in the China Champions League in a team, and recruited the Chongqing football flag Wu Qing. Chongqing Tongliang Dragon has now rushed to China B, attracting the attention of a group of old Lifan generals. Chongqing Tonglianglong can consider introducing Liu Huan whose contract with Guoan expired. After leaving Guoan, Liu Huan went to Dalian for trial training.

Whether Liu Huan can stay in Dalian is a huge unknown. Because Liu Huan’s Dalian team is in a precarious state. Dalian team doesn’t even have the qualification to introduce new aid. If this problem is not solved in the future, Liu Huan will not be able to complete the registration. Therefore, Liu Huan can consider returning to Chongqing. At the same time, Chongqing Tonglianglong chose to play a warm-up match in order to test the training results during this period.

Chongqing Tonglianglong chose to play with Qingdao Manatee, a new Chinese Super League army. Originally, fans thought that Chongqing team would be played by Manatee. Unexpectedly, the Chongqing team was very tenacious in the game and finally defeated its opponent 1-0. The strong play of Chongqing team in the warm-up match made the fans see the hope of rushing to armour. I look forward to Chongqing Tonglianglong’s steady and steady progress in the Chinese B League and achieving the goal of rushing to the first division in the new season.

Paris Saint-Germain is willing to spend 50 million pounds to introduce Maguire?

Paris Saint-Germain is preparing to offer 50 million pounds for Harry Maguire in the summer and bring him to France..

It is reported that Manchester United are willing to break the club record and sign Eduardo Camavinga from Real Madrid for 115 million pounds..

Tottenham Hotspur is facing a struggle to convince Thomas Tuchel to become their new head coach. It is reported that both he and Mauricio Pochettino are the best candidates to succeed Antonio Conte, and Chairman Daniel Levy has reservations about bringing back former head coach Pochettino..

Manchester United has added Mason Mount of Chelsea to the list of attacking midfield targets including ude Bellingham. If Erik ten Hag spends most of his summer budget on bringing in Harry Kane or Victor Osimhen, the summer transfer window will exceed the budget..

The exit of Paris Saint-Germain in the Champions League is likely to prompt the departure of head coaches Christophe Galtier and Sports director Luis Campos..

Considering the cost of living crisis, the soaring business income of Chelsea, the performance of the club this season and the possible impact of the rising ticket fees on the atmosphere of the match day at Stamford Bridge, Chelsea fans warned the club president Todd Boehly that if he decided to raise the ticket price after a bad season at Stamford Bridge, it would cause "irreversible harm" to the fans..

Before Saturday’s game against Brighton, Leeds may get unexpected good news, and striker Rodrigo may play only one month after ankle surgery..

Wolves hope to beat Premier League rivals Tottenham Hotspur and West Ham United and plan to sign Alex Scott of Bristol City for 20 million pounds..

Daniel Levy, chairman of Tottenham Hotspur, will consider a series of candidates to change coaches, including Mauricio Pochettino, who may return to the club, and Luis Enrique, who was fired by Spain after the World Cup. Celtics coach Ange Postecoglou, Brighton coach Roberto De Zerbi and Neapolitan coach Luciano Spalletti..

The beauty created by artificial intelligence AI is lifelike. These 30 beautiful pictures are amazing!

The beauty created by artificial intelligence AI is lifelike and amazing!

The beauty created by artificial intelligence AI is really amazing!

The beauty created by artificial intelligence AI is vivid and beautiful!

The beauty created by artificial intelligence AI is so real and amazing!

The beauty drawn by artificial intelligence AI is vivid and amazing!

The beauty drawn by artificial intelligence AI is real and beautiful! It’s amazing!

The beauty drawn by artificial intelligence AI is amazing! Amazing time!

The beauty drawn by artificial intelligence AI is fresh and refined, so amazing!

This may be the appearance of a small jasper, which is the opposite of the image of a good family! ! ! !

Mature, steady, square, atmospheric, it seems that this is the kind of woman!

There are beautiful women in the north, who laugh and pour people into the city, and then laugh and pour people into the country. This is probably the kind of beauty they are talking about!

Clear water produces hibiscus, which is naturally carved.

Clear water produces hibiscus, and it is natural to carve it! Small jasper, good family! Which is better?

Good-looking skins are the same, and there is no interesting soul Wan Li!

Is the skin beautiful or the soul interesting?

Welcome everyone to comment! ! ! ! !

C Ronaldo’s secret history conjecture: open partner! Ukrainian surrogacy! The mansion is booming!

Recently, foreign media disclosed matters related to the confidentiality agreement of C Ronaldo’s followers, and the private life of this well-known commercial superstar once again aroused fans’ curiosity.

C Ronaldo’s entourage is numerous, including family, friends and staff, including nutritionists, trainers, chefs, cleaners and personal security. Foreign media disclosed: "C Ronaldo’s private life shall not be revealed within 70 years after the death of the player or his last relative."

Considering that Cristiano Ronaldo’s children are less than 10 years old, it is estimated that fans will never have a chance to know about Cristiano Ronaldo’s private life without media coverage. Therefore, this paper boldly makes some guesses about what secrets must be brought to the grave by his followers.

Conjecture 1: open partner

"You can touch my eggs, but not my money." The wife of xiaosheng, a popular national football player, once said this sentence to xiaosan, which shocked the fans, and also unveiled the tip of the iceberg of "open partners" of the rich.

The so-called open partner is to allow your partner to have more partners besides yourself, and you don’t need to be loyal to each other. C Ronaldo and Georgina have been together for many years, and they also have children, but they are not married. Georgina’s external identity is "C Ronaldo’s girlfriend (one of them? ) ",the real identity at home may be the housekeeper (kindergarten director), and this relationship may be an agreement reached between them.

A single girl once told me that she didn’t want to get married because all men were not suitable: 1. If she was a good enough man, there must be other women outside, and few people could withstand the temptation, so it was hard to accept sharing a man with others; 2. If you are not a good man, you will feel frustrated when you look at it, and you don’t want to stay together for a minute.

Some fans have also left a message behind Tang Jiaqi’s article about C Ronaldo: If you have his money and status, you may spend more money than him. At present, the conjecture about Cristiano Ronaldo’s open-ended partner is not only a conjecture, but also some clues. For example, female online celebrity announced that Cristiano Ronaldo cheated during pregnancy.

Online celebrity, a Georgia-Maria, said that she and Cristiano Ronaldo had an intimate relationship in March last year, when Georgina’s twins were pregnant. This happened during the training of the Portuguese national team. For this matter, Cristiano Ronaldo did not deny it. Previously, there seemed to be something else about Cristiano Ronaldo’s affair with his girlfriend Georgina during pregnancy.

There are also fans who question how this female online celebrity’s face value is too low to be liked by the president. In fact, as the saying goes, "Women chase men, and they are separated from each other", the difficulty is actually not that great. As long as the female is active enough, if the fans are lucky enough to have seen all kinds of one-night stands of Cristiano Ronaldo in Manchester United, in fact, this female online celebrity is not the ugliest.

Conjecture 2: Surrogacy in Ukraine

Among C Ronaldo’s children, at least three were born by surrogacy, not including the eldest son, Mini Ronaldo, who is also a surrogate baby. Since many transactions have been made with surrogacy agencies, and C Ronaldo’s daughters (eyes) seem to see the shadow of Ukrainian beauty, C Ronaldo in Europe will make people associate with Ukraine, the "European uterus".

Ukrainian beauties with beautiful skin and long legs are a beautiful scenic line in the world. Because the country is poor, they become surrogate tools.

The price of a Ukrainian woman’s surrogacy is only $30,000, which is one-fifth of that of Europe and the United States. Ukraine ranks among the "European Uterus" with its surrogacy industry of hundreds of millions of dollars every year, which means that thousands of surrogate babies are produced every year. Do C Ronaldo’s surrogate children have Ukrainian babies?

In view of the current Russian-Ukrainian war, Cristiano Ronaldo is openly on Ukraine’s side, announcing that "the world is with you, and I am with you". Is it possible that Cristiano Ronaldo feels the same because he is the father of the Ukrainian baby?

Conjecture 3: Mansion bashing

It’s no secret that the rich in Europe and America are partying in luxury houses. Berlusconi of Italy once held a celestial feast in luxury houses, playing large-scale dramas such as "multi-person sports" and "minors", which is in contrast to the fact that the rich in China only held a "sea-sky feast" on yachts on the high seas.

While rich and prestigious stars have luxury houses all over the world, "using local materials" should not be news. Even if the world "flies", it is not surprising that Neymar has repeatedly staged the drama of "Wan Li calling the way" to invite women from Brazil to Paris, Europe.

There are also many things about the call to C Ronaldo’s mansion. The roles involved are female students, professional workers, online celebrity, nurses, white-collar workers, wives, singers, models, etc. Here, you can search by yourself. These things, I believe that his family’s staff are informed, so it is necessary to sign a confidentiality agreement.

What secrets do you think may be involved in the private life of C Ronaldo staff’s confidentiality agreement?

Haitong Securities: Private cloud will become the mainstream layout of AI big model computing power. It is recommended to pay attention to Pingao shares (688227.SH) and so on.

Zhitong Finance APP was informed that Haitong Securities released a research report saying that AI big model training has less demand for temporary rapid expansion of computing power, and private clouds can also shoulder computing power requirements. At the same time, for continuous and large-scale AI training, private cloud has higher efficiency and lower cost. From a completely visible point of view, with the help of private cloud, enterprises can completely control and visualize their network security status, and can customize it to meet their specific needs. The bank believes that the high security of private cloud makes it a more suitable solution. Suggested attention: Pingao (688227.SH) and Qingyun Technology (688316.SH).

The main points of Haitong Securities are as follows:

AI big model training has less demand for temporary rapid expansion of computing power, and private cloud can also shoulder the computing power requirements.

In the past, China’s public cloud market has always occupied the mainstream position of cloud computing. According to China ICT Institute, in 2021, the scale of China’s public cloud market reached 218.1 billion yuan, while the private cloud market was only 104.8 billion yuan in the same period. In the past, the development of the public cloud market was mainly due to the rapid growth of the demand of Internet enterprises in China in recent years, and the process of traditional enterprises going to the cloud was accelerated, while the public cloud had the advantage of flexibility and easy expansion. The bank believes that in this context, enterprises’ demand for cloud is increasing, while public cloud is easier to expand and more suitable for high-speed growth enterprises. The bank believes that in the context of the current rapid development of AI, the demand for rapid expansion of cloud servers is not so strong; Moreover, from another point of view, before the large-scale model training, there is often a preliminary understanding of the training computing power required by the model, and the required computing power will be prepared and laid out in advance, so it is unlikely that a large amount of computing power will be temporarily expanded during the model training, which makes the advantage that there is a cloud that can rapidly expand no longer exist in the field of AI large models, and the private cloud can also support the computing power demand of model training.

For continuous and large-scale AI training, private cloud has higher efficiency and lower cost.

When building a private cloud, the limited budget can be used efficiently by carefully planning hardware, capacity, storage and network configuration. On the other hand, although the public cloud has some advantages in ease of use, these services have great "binding" characteristics. For example, if users use Microsoft’s pre-trained DNN for image processing, they can’t easily run the generated applications on their own servers, and users can’t use Google’s TPU and AuoML tools in non-Google public clouds. However, in the current training of large models, it is necessary to constantly use new data and functions to keep its "freshness". Because the private cloud is only used by a single organization, the enterprise can completely control its software and hardware selection. This high degree of control means that the owner of the private cloud can reconfigure or customize the cloud resources for the task, further improving efficiency. As the big model becomes more and more complex, private clouds can provide greater generality and finer specifications (such as plugging in specific applications and ensuring continuous availability and data speed independence). The bank believes that on the one hand, the cost of public cloud layout and private cloud layout is basically the same for the demand of fixed pre-trained AI big model. Because there is no demand for rapid expansion, the scale cost advantage of public cloud will be weakened; On the other hand, the training efficiency of public cloud will be lower than that of private cloud specially built for its own AI training. For continuous and large-scale deep learning, using local private cloud can save a lot of costs and improve training efficiency.

Al training needs massive and highly sensitive data, and the high security of private cloud makes it a more suitable solution.

For the public cloud, when companies store their data and information in the cloud, it is difficult to ensure that these data and information will be adequately protected. The huge scale of the public cloud and the diversity of companies covering users also make it a favorite target for hackers to attack. In addition, there is the problem of hardware sharing in public cloud. Through public cloud, the work between different companies will be carried out on the same server, and this sharing mode is likely to lead to the disclosure of confidential data and information. Unlike public cloud, private cloud is a cloud infrastructure specially built to provide "isolated access" in a "single tenant environment", that is, it can only be accessed by a single entity, which is usually an enterprise that uses and maintains the cloud. The only purpose of establishing a private cloud is to provide services for enterprises that own the cloud. From the control point of view, because the owner completely controls the physical computing, storage and network equipment, the data security is promoted to the highest level, and the internal administrator has greater flexibility in implementing and accessing security tools; From a completely visible point of view, with the help of private cloud, enterprises can completely control and visualize their network security status, and can customize it to meet their specific needs. Because AI training needs a lot of data, for example, the data volume of GPT-3 pre-training reaches 45TB; Moreover, the application of artificial intelligence faces great security risks. On the one hand, data is associated with user privacy information, on the other hand, the destruction of the model will lead to decision-making errors, data poisoning will affect the effectiveness of intelligent services, deep forgery will be used for extortion, and data leakage will lead to user privacy exposure. Events occur frequently.Therefore, there will be higher requirements for security. Therefore, the bank believes that a private cloud with high security features is a more suitable solution.